Novel mechanism links p63 and cisplatin resistance
نویسندگان
چکیده
منابع مشابه
Novel mechanism links p63 and cisplatin resistance
Cisplatin, a small-molecule platinum compound, is one of the most effective broadspectrum anticancer drugs. in the clinic, patients usually have a good initial response to cisplatin-based chemotherapy but later relapse because of the development of cisplatin resistance. This resistance is either acquired or intrinsic and markedly reduces the drug’s clinical effectiveness. At the moment, this co...
متن کاملNew extracellular resistance mechanism for cisplatin.
The HSQC NMR spectrum of 15N-cisplatin in cell growth media shows resonances corresponding to the monocarbonato complex, cis-[Pt(NH3)2(CO3)Cl](-), 4, and the dicarbonato complex, cis-[Pt(NH3)2(CO3)2](-2), 5, in addition to cisplatin itself, cis-[Pt(NH3)2Cl2], 1. The presence of Jurkat cells reduces the amount of detectable carbonato species by (2.8+/-0.7) fmol per cell and has little effect on ...
متن کاملA novel regulatory mechanism links PLCγ1 to PDK1.
3-Phosphoinositide-dependent protein kinase-1 (PDK1) and phospholipase C (PLC)γ1 are two key enzymes in signal transduction that control several intracellular processes. Despite the fact that PLCγ1 has been investigated for several years, the mechanisms of activation of this enzyme are still not completely clear. Similarly, although PDK1 has been mostly investigated for its role in activation o...
متن کاملCorrection: A novel regulatory mechanism links PLCγ1 to PDK1.
Fig. 7. Simultaneous inhibition of PDK1 and PLCγ1 does not enhance the effect of inhibition of PDK1 or PLCγ1 alone on cell invasion. (A,B) Results from an invasion assay performed with MDA-MB-231 and A375M cells, respectively, expressing shRNA targeting PLCγ1 or a 3MUT non-targeting sequence, and treated with 1 μM GSK2334470. (C,D) Results from invasion assay performed with the indicated MDA-MB...
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DNA-protein cross-links are formed by various DNA-damaging agents including antitumor platinum drugs. The natures of these ternary DNA-Pt-protein complexes (DPCLs) can be inferred, yet much remains to be learned about their structures and mechanisms of formation. We investigated the origin of these DPCLs and their cellular processing on molecular level using gel electrophoresis shift assay. We ...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2014
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.28215